After looking closely at the log file and comparing to a successful content profile that was executed approx 1 mo ago, it seems the issue may be related to the "profiling engine section".
[I] 2016-02-29 12:34:42.291 [TaskUtility][pool-5-thread-1] Profiling engine section. (TSK-10015)
[E] 2016-02-29 12:34:42.384 [TaskUtility][pool-5-thread-1] (14.2) 02-29-16 12:34:34 (E) (6916:4632) DQX-058306: |Data flow DF_CT_ID_521_1
Transform <Content_Type_Identification>: <UDC0114>: SQLite step failed. Reason: SQL logic error or missing database. SQL
statement: ROLLBACK TRANSACTION.
Any thoughts would be appreciated.